Hip dysplasia in young adolescents

The existing classifications of hip dysplasia are mainly based on radiological measurements of the hip joint, such as the center-edge angle, the acetabular index, and the Tönnis grade. However, these classifications do not capture the diversity and complexity of hip dysplasia, nor do they account for the delivery position, genetic, and biomechanical factors that may have a significant impact on its development and progression.

This research aims to identify different phenotypes of the period from infant to adolescent hip dysplasia based on the 5D hip joint growth data from the Generation R project or other renowned cohort The Rotterdam Study project and to assess whether they have underlying mechanisms and potential trajectories.  
 

The prevalence of hip dysplasia in younger patients underwent THA: The prevalence of hip dysplasia in the general population is estimated at 3-5% based on a largest population scale in Scandinavian area radiographic studies. However, its proportion seems much higher in younger patients undergoing total hip arthroplasty (THA). The Dutch Arthroplasty Register (LROI) reports that dysplasia accounts for 14-15% of hip replacements in patients under 60 years. Joint registry data may overestimate dysplasia rates due to potential misclassification or selection bias. And the independent studies remain regional and small population. The goal of this project is to compare the prevalence of acetabular dysplasia in the contralateral hip between patients with and without acetabular dysplasia in the index hip, to assess whether the presence of dysplasia in the index hip is associated with an increased risk of dysplasia in the contralateral hip.

Funding

HIPSTAR ERC-2021-ADG